An investigation of other-awareness and the collaborative process in low-functioning children with autism using shareable technology

Very little is known about the ability of low-functioning children with autism (LFA) to engage in collaborative activities. Children with autism have deficits in other-awareness, joint attention and imitation, skills considered fundamental in social cognition and associated with the ability to collaborate. Research has focused on identifying the impairments of LFA children’s social interactional abilities in controlled experimental contexts with adult partners. However, there is a paucity of research investigating if LFA children can participate in collaborative activity with peers, and if so what form the collaborative behaviour takes. Children with autism are highly motivated to interact with technology and technology is evolving fast offering opportunities to apply it to research. Therefore, we used innovative technology and a novel software architecture called Separate Control of Shared Space (SCoSS) on three types of shareable computer technology to aid our investigation of other-awareness and collaboration in LFA children. Paper 1, describes two studies using a dual-control laptop to present picture-sorting tasks to children paired with an adult and peer. SCoSS was more effective at facilitating other-awareness in TD and LFA children than a standard interface. Crucially, LFA children showed no active other-awareness without the supportive interface. Paper 2 presented two different picture-sorting problems for pairs of LFA children to solve. This yielded a model of collaborative problem-solving based on a sequence of three prerequisite capacities. Paper 3 successfully applied the SCoSS framework to picture-sequencing tasks delivered via tablet technology. As in paper 1, pairs of LFA children were only actively aware of a peer using linked dual-tablets, analogous to SCoSS. In summary, the thesis presents evidence that the other-awareness of LFA children can be facilitated by technology to support collaborative problem-solving, providing a more complete profile of their abilities and offers evidence that LFA are sensitive to the type of collaborative partner

Teach For America Teachers\u27 Blogs on Teaching

In 1989, Princeton University senior Wendy Kopp conceived the idea of a national teacher corps that would place the brightest young people in the schools that were the most difficult to staff. This idea, which became Teach For America (TFA), took life in 1990, and has since become a powerful force in the public education reform movement. TFA consistently attracts college graduates from the nation’s top universities, and with the funding it receives from private donors as well as the federal government, the organization recruits and trains these individuals who commit to teach in the country’s highest-needs public schools. Critics of Teach For America, including the National Education Association (NEA) and scholar Linda Darling-Hammond—whose 1994 critique of TFA nearly destroyed the organization, argue that TFA poses a threat to the future of public education because it places the most inexperienced teachers in the country’s most struggling schools. While politicians, CEOs, prominent educators, teachers unions, and celebrities engage in debates on whether TFA teachers have a positive or negative impact on students, the voices of Teach For America teachers themselves have been largely left out of this conversation. This study identifies their attitudes, concerns, and anxieties about teaching by analyzing the blogs of fifteen different TFA teachers on the Teach For Us blogging network. It found that Teach For America teachers felt unprepared for the work of teaching, the culture of the schools where they were placed, and the academic level of their students, yet maintained an optimistic attitude in spite of these feelings

Beyond autism and technology: lessons from neurodiverse populations

Purpose – This short paper reports on the sixth seminar in a 7-seminar series entitled, “Innovative Technologies for Autism: Critical Reflections on Digital Bubbles”, funded by the UK Economic and Social Research Council (ESRC). The aim of this particular seminar was to reflect upon the implications from neurodiverse communities for the development of technology for autism. Design/methodology/approach – Presentations from key researchers and parental perspectives are reviewed, highlighting contemporary issues in neurodiverse populations that have important implications for autism. Findings – Whilst there are many conditions associated with autism, most commonly intellectual disability (learning difficulties), this is not reflected in research. In addition, for child-based research, researchers are at least a generation older than participants and have had different digital-childhoods. Involving neurodiverse populations within participatory design sessions can address both of these issues. Understanding the context of the issues that the participatory design sessions address is crucial for developing participatory design principles that extend from one condition to another. This includes understanding when findings based upon verbal populations can be extended to nonverbal populations. Originality/value – This paper offers up-to-date insights into how design principles from one condition extend to different conditions. Universal interaction and neurodiversity HCI are considered. This is important within neurodiverse populations, especially given the high rates of additional conditions that are associated with autism. Whilst the majority of autism research has involved verbal populations, the benefits of technology can extend to non-verbal populations

Parent-reported experience of using a real-time text messaging service for dental appointments for children and young people with autism spectrum conditions: a pilot study

Introduction: Children and young people (CYP) with autism spectrum conditions (ASCs) and their parents/carers find dental appointments stressful. Consultation with parents of CYP with ASC identified time spent in dental waiting areas as contributing to dental anxiety. Parents proposed waiting outside the dental practice until the clinician was ready could help mitigate anxiety. Aims: To evaluate a real‐time text messaging service (RTMS) to improve dental attendance experience for CYP with ASC. Methods: An RTMS was developed for use in the dental clinic. Parents/carers of 17 CYP with ASC (4 to 20 years) attending a Special Care Dental service were invited to share their dental experience and the impact of using the RTMS. Results: Parent experience suggests that time in waiting areas can increase anxiety in CYP with ASC. All parents viewed the RTMS as having a positive impact on CYP dental attendance experience. The majority believed that it reduced anxiety and enabled CYP to be more accepting of dental treatment. Discussion: Many CYP with ASC have dental anxiety exacerbated by the use of waiting areas. Findings demonstrate the importance of considering and developing a range of approaches that respond to the needs of CYP with ASC and their families to improve dental attendance experience

Loss of α-Calcitonin Gene-Related Peptide (αCGRP) Reduces Otolith Activation Timing Dynamics and Impairs Balance

Calcitonin gene-related peptide (CGRP) is a neuroactive peptide that is thought to play a role at efferent synapses in hair cell organs including the cochlea, lateral line, and semicircular canal. The deletion of CGRP in transgenic mice is associated with a significant reduction in suprathreshold cochlear nerve activity and vestibulo–ocular reflex (VOR) gain efficacy when compared to littermate controls. Here we asked whether the loss of CGRP also influences otolithic end organ function and contributes to balance impairments. Immunostaining for CGRP was absent in the otolithic end organs of αCGRP null (-/-) mice while choline acetyltransferase (ChAT) immunolabeling appeared unchanged suggesting the overall gross development of efferent innervation in otolithic organs was unaltered. Otolithic function was assessed by quantifying the thresholds, suprathreshold amplitudes, and latencies of vestibular sensory-evoked potentials (VsEPs) while general balance function was assessed using a modified rotarod assay. The loss of αCGRP in null (-/-) mice was associated with: (1) shorter VsEP latencies without a concomitant change in amplitude or thresholds, and (2) deficits in the rotarod balance assay. Our findings show that CGRP loss results in faster otolith afferent activation timing, suggesting that the CGRP component of the efferent vestibular system (EVS) also plays a role in otolithic organ dynamics, which when coupled with reduced VOR gain efficacy, impairs balance

Ear and hearing care programs for First Nations children: a scoping review

BACKGROUND: Ear and hearing care programs are critical to early detection and management of otitis media (or middle ear disease). Otitis media and associated hearing loss disproportionately impacts First Nations children. This affects speech and language development, social and cognitive development and, in turn, education and life outcomes. This scoping review aimed to better understand how ear and hearing care programs for First Nations children in high-income colonial-settler countries aimed to reduce the burden of otitis media and increase equitable access to care. Specifically, the review aimed to chart program strategies, map the focus of each program against 4 parts of a care pathway (prevention, detection, diagnosis/management, rehabilitation), and to identify the factors that indicated the longer-term sustainability and success of programs. METHOD: A database search was conducted in March 2021 using Medline, Embase, Global Health, APA PsycInfo, CINAHL, Web of Science Core Collection, Scopus, and Academic Search Premier. Programs were eligible or inclusion if they had either been developed or run at any time between January 2010 to March 2021. Search terms encompassed terms such as First Nations children, ear and hearing care, and health programs, initiatives, campaigns, and services. RESULTS: Twenty-seven articles met the criteria to be included in the review and described a total of twenty-one ear and hearing care programs. Programs employed strategies to: (i) connect patients to specialist services, (ii) improve cultural safety of services, and (iii) increase access to ear and hearing care services. However, program evaluation measures were limited to outputs or the evaluation of service-level outcome, rather than patient-based outcomes. Factors which contributed to program sustainability included funding and community involvement although these were limited in many cases. CONCLUSION: The result of this study highlighted that programs primarily operate at two points along the care pathway-detection and diagnosis/management, presumably where the greatest need lies. Targeted strategies were used to address these, some which were limited in their approach. The success of many programs are evaluated as outputs, and many programs rely on funding sources which can potentially limit longer-term sustainability. Finally, the involvement of First Nations people and communities typically only occurred during implementation rather than across the development of the program. Future programs should be embedded within a connected system of care and tied to existing policies and funding streams to ensure long term viability. Programs should be governed and evaluated by First Nations communities to further ensure programs are sustainable and are designed to meet community needs

Mitochondrial Transcription Terminator Family Members mTTF and mTerf5 Have Opposing Roles in Coordination of mtDNA Synthesis

Peer reviewe

Pandemic Preparedness and Response in the Age of Technology

The Fourth Annual White Paper from the Scowcroft Institute of International Affairs at The Bush School of Government & Public Service at Texas A&M UniversityEffective pandemic preparedness and response depend on the quality as well as the speed of obtaining relevant information, especially from remote and hard to reach areas of the world, where most known and unknown disease outbreaks occur and originate. Equally important is the local/national ability to collate, analyze, and interpret the information in a form valuable for taking appropriate preventive action and response. For web-based surveillance systems to be more effective, it is important that the capacity to collate, analyze, interpret, and disseminate the information in a form that results in appropriate preventive action and response in the countries where these diseases originate. The COVID-19 pandemic has demonstrated the ability to obtain information from different sources and dissemination of such information globally. Despite the availability of information on the development of the pandemic from a Public Health Emergency of International Concern (PHEIC), many countries were unprepared when the pandemic finally reached their borders. It is not enough for countries to efficiently analyze disease surveillance data, they must actively prepare to prevent the entry of a disease into their territory and, at the same time, prepare plans and identify and initiate containment measures that need to be taken to prevent the establishment of the disease in the country

AMPK is a mechano-metabolic sensor linking cell adhesion and mitochondrial dynamics to Myosin-dependent cell migration

Cell migration is crucial for cancer dissemination. We find that AMP-activated protein kinase (AMPK) controls cell migration by acting as an adhesion sensing molecular hub. In 3-dimensional matrices, fast-migrating amoeboid cancer cells exert low adhesion/low traction linked to low ATP/AMP, leading to AMPK activation. In turn, AMPK plays a dual role controlling mitochondrial dynamics and cytoskeletal remodelling. High AMPK activity in low adhering migratory cells, induces mitochondrial fission, resulting in lower oxidative phosphorylation and lower mitochondrial ATP. Concurrently, AMPK inactivates Myosin Phosphatase, increasing Myosin II-dependent amoeboid migration. Reducing adhesion or mitochondrial fusion or activating AMPK induces efficient rounded-amoeboid migration. AMPK inhibition suppresses metastatic potential of amoeboid cancer cells in vivo, while a mitochondrial/AMPK-driven switch is observed in regions of human tumours where amoeboid cells are disseminating. We unveil how mitochondrial dynamics control cell migration and suggest that AMPK is a mechano-metabolic sensor linking energetics and the cytoskeleton. Cell metabolism must adapt to the energy needs of migrating cells. This study finds that fast amoeboid migrating cells harbor high AMPK activity, which controls both mitochondrial dynamics and cytoskeletal remodeling, enabling reduced energy needs

Doctoral Chamber Recital

List of performers and performances